Stanford type A (proximal) aortic dissection accounts for ~60% of all aortic dissections

Classic treatment includes direct surgical replacement of the ascending aorta w/prosthetic graft (+/- AV  aortic repair/replacement)

~20-30% of these patients (*institutional dependent) are considered poor candidates for surgery and receive only medical management, which innately results in substandard outcomes

In this study those who were considered poor candidates for surgical repair underwent novel endovascular treatment

Endovascular repair in this study was considered both appropriate and improved traditional medical outcomes in patients who were considered poor candidates 

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Trapezium Fractures

• The trapezial body is often fractured due to an axial load through the thumb
• The trapezial ridge is often fractured during a fall on an outstretched hand
• Accounts for 1% to 5% of all carpal fractures.

Suspect the Diagnosis when you note

• Tenderness  over trapezium 
• Often have increased pain with axial loading of thumb.
• Point tenderness at the volar base of the thumb just distal to the scaphoid, at the base of the first metacarpal.
• Since the trapezium is obscured by superimposed bones in PA and lateral views, fractures are most easily identified on the oblique radiographs

If you are suspected the diagnosis oblique radiographs or a CT scan of the wrist will note the fracture the best.

Treatment consists of placing the patient in a thumb spica splint.

• enterovirus which lives in digestive tract, and is highly contagious
• outbreaks worse in summer and fall, but is a self-limited illness
• causes mild flu-like symptoms such as fever, headache, muscle aches, sore throat. with fever usually lasting less than 3 days
• hand, foot, and mouth disease: syndrome of painful blisters in oropharynx and plams of hands and soles of feet
• herpangina: painful blisters in oropharynx, usually posterior in location
• hemorrhagic conjunctivitis: eye pain with injected conjunctivia
• serious complications include: viral meningitis and encephalitis, myocarditis, and secondary bacterial infections

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In the treatment of acetaminophen poisoning with N-acetylcysteine (NAC), the PT/INR can be slightly elevated even in the absence of hepatotoxicity. Considering Prothombin Time (PT) is one of the criteria used to assess severity of liver damage in this setting, it is important to know how much the PT/INR can be affected by NAC and if it has an actual effect on coagulation factor levels.

1. N-acetylcysteine has been shown to slightly increase the PT) by up to 3.5 seconds in healthy volunteers.
2. A more recent study by the same authors demonstrated a reduction in vitamin K-dependent clotting factor activity (II, VI, IX, and X) after NAC administration in healthy volunteers.

Clinical Practice Pearls

• The elevation in PT/INR after NAC administration is real, not simply laboratory interference.
• However, the PT/INR elevation and decrease in coagulation factors is modest and not likely clinical signficant.
• Many poison center guidelines allow for an INR up to 2 to be considered 'normal' to account for this phenomenon in this setting.

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General Information:

-Listeria can cause serious infections in vulnerable groups: adults >65 years old, pregnant women, newborns, immunocompromised

-In a recent CDC report, infection with Listeria was associated with a 20% mortality rate.

Clinical Presentation:

- History of cantaloupe, soft cheese, or raw produce ingestion

- Non-specific symptoms: fever, myalgias, occasionally preceded by GI symptoms

-Can have headache, stiff neck, confusion, AMS, miscarriage or stillbirth in pregnant women

Diagnosis:

- Blood, CSF, or amniotic fluid culture showing Listeria monocytogenes

- Listeria is a reportable disease

Treatment:

- Ampicillin and Penicillin G are the drugs of choice

- Add gentamycin in CSF infection, endocarditis, the immunocompromised, and neonates.

Bottom Line:

Listeria infections have a high mortality rate and can be found worldwide.  Suspect in patients who have febrile syndromes and travel to areas where they may consume unpasteurized cheese.

University of Maryland Section of Global Emergency Health

Author: Andi Tenner, MD, MPH

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Rhabdomyolysis in the Critically Ill

• Rhabdomyolysis can be disastrous in the critically ill patient, resulting in metabolic acidosis, life-threatening hyperkalemia, acute kidney injury, and acute renal failure (ARF).  In fact, mortality can be as high as 60% for those that develop ARF secondary to rhabdomyolysis.
• Although creatine kinase (CK) is a sensitive marker of muscle injury and used for diagnosis, it is actually the presence of myoglobinuria that results in ARF.
• Current guidelines recommend treatment when the CK level is > 5000 U/L.
• The mainstay of treatment remains aggressive fluid resuscitation with crystalloids.
• The administration of bicarbonate to alkalinize the urine, diuretics to increase urine output, and osmotic agents (mannitol) to augment urine output remain controversial and are not supported by current literature.

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Question

13 year-old female with ankle pain following fall down escalator. What's the diagnosis?

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• Syncope is a sudden lack of blood supply to the brain typically caused by a problem in the regulation of blood pressure or a problem with the heart
• Syncope can be broadly classified in 3 categories neural reflex (~60%), orthostatic (~15%), and cardiac (~15%) 
• >Even in the absence of a firm diagnosis of cardiac syncope, the presence of known structural heart disease (CAD) or evidence a primary electrical disorder is associated with a poor prognosis
• Cardiac causes of syncope can also be divided into 3 categories: structural heart disease, obstructive lesions, and arrhythmogenic potential
  • Structural: Ischemic heart disease, dilated cardiomyopathy, ARVD, 
  • Obstructive: HCM, aortic/mitral stenosis, atrial myxoma, pulmonary HTN, PE, tamponade
  • • Brady: AV block, sick sinus, sinus arrest/pause
    • Tachy: SVT (AVNRT/AVRT), accessory pathways (WPW), or primary arrhythmias (LQTS, SQTS, CPVT, Brugada) 

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The adolescent brain has not yet reached full maturation and is in a period of rapid development from ages 14 - 16. 

Adolescents have been found to be more sensitive to the effects of concussion than adults

Concussed adolescents have deficits in attention and executive function lasting up to 2 months post injury.

Be aware that the adolescent brain will require  extended recuperation time following injury

In the future, discharge instructions might need to say more than "don't get hit in the head till your headache goes away." Because of deficits in attention and executive function, physicians should consider recommendations about adolescents and jobs, school work and driving an automobile. 

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Infant lumbar puncture is often difficut and may require repeated attempts.  The traditional body positioning is lateral decubitus.  Previous studies have examined the saftey of having the patient in a sitting position, and neonatal studies have suggested that the subarachnoid space increases in size as the patient is moved to the seated position.  A study by Lo et al published last month looked to see if the same held true in infants.
 
50 healthy infants less then 4 months old had the subarachnoid space measured by ultrasound between L3-L4 in 3 positions: lateral decubitus, 45 degree tilt and sitting upright.
 
This study found that the size of the subarachnoid space did not differ significantly between the 3 positions.  Authors postulated that a reason for increase sitting LP success rate that had been reported in anestesia literature with tilt position could be due to other factors such as increased CSF pressure, intraspinous space widening or improved landmark identification.

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• Opioid analgesia can actually INCREASE sensitivity to pain in some cases

• The exact cause is unclear, but may be due to up-regulation of NDMA receptors in spinal cord dorsal horn neurons

• Pain tends to be DIFFERENT and DIFFUSE from the underlying condition for which the narcotics were prescribed

• Switching from shorter acting opiates to methadone may be effective, as it is a weak NDMA antagonist and has only partial cross tolerance with other opioids

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General Information:

-The global health world is faced with an unprecedented challenge of a trio of threats:

     1. Infections, undernutrition, reproductive health issues

     2. Rising global burden of non-communicable diseases and risk factors

     3. Challenges arising from globalization (climate change and trade politics)

-Definitions of global health are variable and can emphasize anything from types of health problems, populations of interest, geographic area or a specific mission.  This makes governance and analysis difficult.

-During the past decade there has been an explosion of more than 175 initiatives, funds, agencies, and donors.  Health is increasingly influenced by decisions made in other global policymaking areas.

-The major governance challenges for global health are:

     1. Defining national sovereignty in the context of deepening health interdependence

     2. Maximizing cross-sector interdependence

     3. Developing clear mechanisms of accountability for non-state actors

Relevance to the US physician:

The Global Health System and its governance affects our ability to work effectively within the US and how we structure efforts to expand the reach of timely, effective emergency care worldwide.

Bottom Line:

The Global Health System has become more complex. Any development of Emergency Care Systems must take into account the complexity of actors in the field of global health.

The University of Maryland Section of Global Emergency Health

Author: Emilie J. B. Calvello, MD, MPH

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Therapeutic hypothermia (TH) following out-of-hospital cardiac arrest (OHCA) has increasingly been utilized since it was first described. TH following in-hospital cardiac arrest (IHCA), on the other hand, is not as commonplace or consistent despite a recommendation by the American Heart Association (AHA).

A recent prospective multi-center cohort-study demonstrated that of 67,498 patients with return of spontaneous circulation (ROSC) following IHCA only 2.0% of patients had TH initiated; of those 44.3% did not even achieve the target temperature (32-34 Celsius). 

The factors found to be most associated with instituting TH were:

• Younger patients
• Admission to non-ICU units
• Arrests occurring Monday through Friday (as compared to weekends)
• Arrests within teaching hospitals (as compared to non-teaching institutions)

Bottom-line: Hospitals should consider instituting and adhering to local TH protocols for in-house cardiac arrests.

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Ever wonder how to place a pigtail catheter?

Check out this video to learn how, click here

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• Mirror-image dextrocardia is the most common form of cardiac malposition and is commonly associated with situs inversus of the abdominal organs
• The anatomic right ventricle is anterior to the left ventricle and the aortic arch curves to the right and posteriorly
• 25% percent of these patients will have associated sinusitis and bronchiactasis (Kartagener’s syndrome)
• ECG changes associated with dextrocardia include:

1. Right-axis deviation
2. Global negativity in leads I and aVL (negative QRS w/inverted P and T waves)
3. Lead aVR similar to the normal aVL (positive QRS)
4. Absent R wave progression in precordial leads/dominant S waves

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Background

In the current era of community-acquired MRSA (CA-MRSA), most of our outpatient treatment options for cellulitis aim to cover MRSA. Choices include sulfamethoxazole/trimethoprim (SMZ-TMP), doxycycline, linezolid, and clindamycin (depending on local susceptibility patterns).

A New Study

• In a double-blind, placebo-controlled trial 146 patients with cellulitis were randomized to receive cephalexin alone or cephalexin + SMZ-TMP for 7-14 days
• Lots of exclusion criteria basically narrowed the patient population to uncomplicated cellultits with no history of diabetes or other immunocompromising conditions
• Cure rates up to 30 days post-treatment were the same between the two groups (>80%)

Take Home Clinical Points

• Even in communities with high prevalence of MRSA, uncomplicated cellulitis cases without pus generally seem to be strep species.
• Therefore, make sure to include an anti-streptococcal component (such as cephalexin) to the MRSA agent (doxycycline or SMZ-TMP). Clindamycin has sufficient strep coverage by itself (but may not adequately cover MRSA).
• Given the potential for MRSA infections to deteriorate quickly and the inability to differentiate staph from strep without cultures, MRSA coverage should still be considered.

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Hyperglycemia in the setting of antipsychotic use has been reported mostly with olanzapine (Zyprexa) but does occur with other antipsychotics. A recent study from the NYC medical examiner's office details 17 deaths of DKA due to antipsychotics and found that (from highest to lowest incidence) quetiapine > olanzapine > risperidone were the atypical antipsychotics found with these deaths.

Remember hyperglycemia occurs with patients on antipsychotics and can lead to hyperglycemia hyperosmolar coma or DKA. Both can be lethal.

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Background Information:

Each year, an estimated 50 million travelers from Western countries visit tropical regions all over the world.

Given the potentially serious consequences for the patients and, their close contacts and healthcare workers it is important that life threatening tropical diseases are swiftly diagnosed.

Pertinent Study Design and Conclusions:

- Descriptive analysis of acute and potentially life threatening tropical diseases among 82,825 ill western travelers reported to GeoSentinel from June of 1996 to August of 2011.

- Of these travelers, 3,655 (4.4%) patients had an acute and potentially life threatening disease.

- The four most common conditions being falciparum malaria (76.9%), typhoid fever (11.7%), paratyphoid fever (6.4%), and leptospirosis (2.4%).

Bottom Line:

Western physicians seeing febrile and recently returned travelers from the tropics need to consider a wide profile of potentially life threatening tropical illnesses, with a specific focus on the most likely diseases described in this case series.

University of Maryland Section of Global Emergency Health

Author:  Walid Hammad, MB ChB

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End-expiratory Occlusion Test

• Volume expansion is a cornerstone of resuscitation for circulatory failure.
• As discussed in previous pearls, only 50% of unstable critically ill patients respond to fluid therapy.  For the 50% that don't respond, additional fluids may increase morbidity and mortality.
• In recent years, there has been tremendous focus on dynamic markers of fluid responsiveness, including respirophasic changes in IVC diameter, passive leg raising, and pulse pressure variation (PPV).
• An additional dynamic marker of fluid responsiveness is the end-expiratory occlusion test.
• Unlike PPV, this test can be performed on patients with spontaneous breathing activity and those with cardiac arrhythmias.
• Recent literature indicates that a 5% increase in cardiac output during a 15-second end-expiratory occlusion test predicts a positive response to a 500 ml saline infusion.

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Question

9 month-old presents with wheezing and the CXR is shown below. What's the diagnosis?

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