- Dapsone has been used to treat leprosy but more commonly to in brown recluse spider bites and to prevent PCP pneumonia and toxoplasmosis in our HIV population
- It can cause methemoglobinemia: a reduced form of iron (ferrous to ferric) in the Hb molecule that decreases your oxygen carrying capacity.
- Due to its color, cyanosis is a predominant symptom out of proportion to symptoms.
- Treatment: Methylene Blue 1-2 mg/kg IV
- Pitfall: Dapsone's long half-life may cause reoccurrence of MetHb and require retreatment