Bottom line: As part of a systematic protocol, peripheral pressors administered through a peripheral line greater 22Ga or larger reduced the number of days of central venous catheter (CVC) use in a MICU population at an academic medical center. 35 (5.5%) patients had an extravasation event all with “minimal” tissue injury complications. None required surgery. 51.6% of patients did not require a CVC as a result of the protocol

 

Details

• Six hundred thirty-five patients received peripherally administered norepinephrine.
• The median number of CVC days avoided per patient was 1 [IQR 0, 2] days
• 311 patients (51.6%) never required CVC insertion.
• Extravasation of norepinephrine occurred in 35 patients (75.8 events/1,000 d of PIVC infusion [95% CI, 52.8-105.4 events/1,000 d of PIVC infusion]).
• Most extravasations caused no or minimal tissue injury.
• No patient required surgical intervention.

 

Notes on protocol

PIV were placed and confirmed with US, were between wrist and AC fossa with q2h patency checks. Max allowable dose of NE 15 mcg/min with requirement that patients be able to report pain at site. Initially, max infusion time was set at 48h but was eventually liberalized to indefinite use. 

 

References

https://pubmed.ncbi.nlm.nih.gov/37611862/