Management of Coagulopathy in Acute Liver Failure

• Patients with acute liver failure (ALF) frequently require rapid resuscitation to prevent decompensation and multiorgan failure.
• The most common cause of ALF remains drug-induced injury (i.e., acetaminophen).
• Though coagulopathy is common in patients with ALF, the prophylactic administration of blood products has not been shown to have clinical benefit.
• The routine correction of coagulation abnormalities is not currently recommended, unless the patient undergoes a major procedure (e.g., liver transplant).

References

Trovato FM, et al. Update on the management of acute liver failure. Curr Opin Crit Care. 2019; 25:157-164.