Title: "Malignant" Mitral Valve Prolapse (MVP)

Posted: 8/5/2013 by Semhar Tewelde, MD

Classically MVP is considered a benign diagnosis associated w/palpitations, atypical chest pain, dyspnea, and carries a low risk of complications
A recent study investigated MVP and its association w/ventricular arrhythmias in a cohort of unexplained out-of-hospital cardiac arrest (OHCA)
A small subset of patients w/MVP experienced life threatening arrhythmias coined "malignant" MVP
Malignant MVP was most often associated w/female sex, bileaflet valve, and frequent complex ventricular ectopic activity

References

Sriram C, Syed F, Ferguson E, et al. Malignant Bileaflet Mitral Valve Prolapse Syndrome in Patients With Otherwise Idiopathic Out-of-Hospital Cardiac Arrest. JACC 2013;62:222-30