SSRI Toxicity

Things to watch for in patients that are taking SSRI:

• Therapeutic administration usually safe
• Hyponatremia is a common adverse effect (ADH secretion regulated by serotonin)
• Serotonin Syndrome is a possibilty in combination with other serotnergic drugs
• One SSRI is more problematic than the rest => Citalopram and Escitalopram
  • The only SSRI that can cause QT prolongation (even 24hrs after OD) and can cause seizures
  • This is the only SSRI with significant toxicity and unfortunately is the most commonly Rx by psych