If vancomycin resistance is suspected with MRSA infections, there are several other antibiotic choices. They are all extremely expensive.
| Antibiotic | ORAL | Indication | Precaution |
| Telavancin | N | SSTI | May cause QT prolongation: Caution with azole antifungals, class III antiarrhythmics, antidepressants, antipsychotics. Interferes with coagulation tests. |
| Daptomycin | N | SSTI Bacteremia Endocarditis | Not for pneumonia. May cause rhabdomyolysis; Discontinue statins. |
| Linezolid | Y | VAP SSTI | Not for bacteremia. May cause serotonin syndrome; Caution with antidepressants, antipsychotics, tramadol, methadone. |
| Tigecycline | N |
Intrabdominal infections SSTI | Not for bacteremia. Inhibits clearance of warfarin. Reserve for polymicrobial infections. |
Skin and soft tissue infection (SSTI); ventilator acquired pneumonia (VAP)