• Sulfonyurea overdose is associated with hypoglycemia, which may be delayed and prolonged.
• Treatment with dextrose results in hyperglycemia, which potentiates insulin release from the pancreas, resulting in recurrent hypoglycemia.
• Octreotide mimics somatostatin, which suppresses the secretion of glucagon and insulin, among others.
• Octreotide binds with somatostatin receptors, closing calcium channels, preventing the influx of calcium and subsequent insulin release.
• The dose is 100 mcg SUBCUTANEOUSLY, repeated every 8 hours as needed.

References

Dougherty PP, Klein-Schwartz  W. J. Med Toxicol 2010;6:199-206.