Lithium: Hypothyroidism (5-15% of pts) and goiter (37% of pts), mechanism unclear
Amiodarone (37% Iodine by weight): Hyper or Hypothroidism
Beta-Blockers: by blocking peripheral conversion of T4 to T3 cause hypothyroidism
Corticosteroid: same as beta-blockers but can also cause transient thyrotoxicosis (Jod-Basedow effect)
Iodine, Iodinated contrast, radiactive iodine all can cause hypothyroidism but iodinated contrast material can actually induce thyrotoxicosis and thyroid storm from unknown mechanism.
